The quest to make a global vaccine in 12 months

The quest to make a global vaccine in 12 months

Vaccines by themselves do not save lives, but rather the immunisation process does. This highlights a challenge the world is facing right now. The process used to create a vaccine in a laboratory is different to the one used for bulk manufacturing by the pharmaceutical industry in order to immunise people.

We already manufacture billions of doses of vaccines every year, from the annual influenza jab to the combined measles, mumps and rubella (MMR) immunisation. The 2009 swine flu pandemic, which saw the death of hundreds of thousands of people, lead to approximately three billion doses of flu vaccines being produced and delivered within six months.

Developing a new vaccine is a lengthy process. The 2014 to 2016 Ebola outbreak in West Africa resulted in the death of more than 11,000 people. Scientists with the Public Health Agency of Canada had been working on the rVSV-ZEBOV vaccine since 2003 and it was only during the Ebola outbreak that the vaccine’s clinical trials were actually conducted. It was successfully concluded in November 2016 and was approved three years later following a further trial study with 15,000 people.

Creating and manufacturing an entirely new vaccine on a national or global scale, whilst maintaining production of all the other vaccines, becomes a Herculean endeavour, experts say. “We’re making a vaccine for a virus that we’ve never made a vaccine for, that’s not approved, using platforms that haven’t been used extensively in the clinic with patients,” explains Angela Rasmussen, a virologist at Columbia University’s Center for Infection and Immunity.

Conventionally, vaccine research can take 10 years from initial development through to mass distribution. However, for Covid-19, there is a global effort to reduce that to only 18 months, whilst maintaining the same safety standards.